A protease variant having modified immunogenicity as compared to a parent protease, obtainable by a method comprising the steps of: (a) obtaining antibody binding peptide sequences, (b) using the sequences to localise epitope sequences on the 3-dimensional structure of the parent protein, (c) defining an epitope area including amino acids situated within 5 Å from the epitope amino acids constituting the epitope sequence, (d) changing one or more of the amino acids defining the epitope area of the parent protein by genetic engineering mutations of a DNA sequence encoding the parent protein, (e) introducing the mutated DNA sequence into a suitable host, culturing said host and expressing the protein variant, and (f) evaluating the immunogenicity of the protein variant using the parent protein as reference.ġ36. Renal progenitor cells from embryonic stem cellsĪnnexin and p34 promoters and use in expression of transgenic genes in plantsġ35. Process of Producing Ethanol Using Starch with Enzymes Generated Through Solid State Culture Novel human genes and proteins encoded thereby Mouse olfactory receptor gene superfamily Use of Bufodienolides in Diagnosing and Treating Essential Hypertension

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